Human/Human Co-Culture Model
Biliary Tree Stem Cells
Fibrolamellar Cancer Cells
Custom Media Program
Neural Products catalog
Hepatic Products catalog
Neural Models 2016
Scalable and Mature Human Neurons catalog
CryoNeurons™ catalog: Cryopreserved Human
Richard Malavarca, President
Co-founder of PhoenixSongs, Richard
Malavarca has principal responsibility for the development and
production of media formulations to support novel in house stem
cell based model systems as well as client interactions with other
customers to develop stem cell media components on a contract basis.
Malavarca brings over 30 years of experience in research and product
development in both academic and commercial laboratories including
Harvard medical school, the Roche institute, and Merck. Mr.
Malavarca founded Specialty Media (now a part of Millipore), which was
the first company to introduce commercial media for Murine embryos as
well as Murine embryonic stem cells. In addition, he was co-founder of
Cell and Molecular Technologies (now a part of Life
Technologies), a CRO which developed animal models, cell lines, and
supplied ready to use cells to pharmaceutical companies for cell based
high throughput screening. Upon the sale of his companies, Mr.
Malavarca was Director of R&D for the stem cell product area at
Millipore and most recently director of expression technologies
developing novel upstream products for Millipore’s Bioprocess division.
Mr. Malavarca received his BS in biology in from Boston College.
Marsha Roach, Executive Vice President
of PhoenixSongs, Marsha Roach leads a scientific team to develop stem
cell-derived cellular model by isolating stem/progenitor cells from
multiple human tissues, including but not limited to liver, biliary
tree, brain, umbilical cord, and then differentiating them into
functionally mature cell types for research and drug
discovery. Ms. Roach manages external partnerships with many of
the leading pharmaceutical companies, Contract Research Organizations,
other biotech companies and academic collaborators to develop these
stem cell-derived model systems and validate function compared to gold
her 14-year tenure at Pfizer, she pioneered the use of stem
cell-derived cell types in drug discovery. Ms. Roach developed the
first stem cell-derived neural model that was used in an industry-first
high throughput screen that screened 2.4 million small molecules which
resulted in the discovery of novel small molecule AMPA type glutamate
receptor potentiators. In addition Ms Roach lead a research team in
producing ES cell-derived hepatocytes that were functionally
indistinguishable from primary hepatocytes in drug metabolism assays.
at Pfizer, Ms Roach also had an Adjunct Faculty position with Dr. Jerry
Yang at the Center for Regenerative Biology, University of Connecticut.
In this position Ms Roach taught stem cell technology to graduate
students, post doctoral fellows and faculty. Embryonic stem cell lines
were isolated from mouse, rabbit and bovine blastocyst stage embryos.
Roach earned her Bachelor of Science and Master of Science degrees from
the University of Illinois in the area of animal science, molecular
embryology and developmental biology. While earning her Master’s
degree, she also worked as a Research Specialist managing an embryology
Lola M. Reid, PhD, Founder and Chief Scientific Officer
Founder of PhoenixSongs, Dr. Reid has
more than 30 years of experience in doing cell and molecular biological
studies on differentiated epithelial cells in culture, on matrix
biology and chemistry, proteoglycan/glycosaminoglycan biology and
chemistry, and on stem cell biology particularly of murine, rat and
human livers, human biliary tree tissues and, most recently, human
Reid and associates have published the first reports of the
identification, isolation (by immunoselection technologies) and
establishment in culture under wholly defined conditions of rodent
hepatoblasts, rodent hepatic stellate cell precursors, human hepatic
stem cells and hepatoblasts, and most recently, biliary tree stem cells
and pancreatic progenitors.
biliary tree stem cells are multipotent and give rise to liver, biliary
tree and to pancreas in a process that increasingly suggests ongoing
organogenesis of liver and pancreas throughout life. The precursors
located entirely within the pancreas are, in fact, committed
progenitors.In addition, Dr. Reid and associates have established
serum-free, hormonally defined media and defined matrix substrata for
cultures of these cells and their native mesenchymal cell partners
(angioblasts, endothelial cells, stellate cells).
background and experience establish Dr. Reid as a though leader in the
areas of endodermal stem cell populations, lineage biology in liver,
biliary tree and pancreas and 2-dimensional and 3-dimensional cultures
of differentiated cells under wholly defined conditions.