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Fibrolamellar Cancer Cells

Now available: FLC tumor cells from the patient-derived xenograft (PDX) model. See our Hepatic Product Catalog PDF or order online from our shopping cart.

Article in Nature Communication

We want to thank the Davis family and the Fibrolamellar Cancer Foundation. A percentage of the proceeds will be donated to the Foundation.

Fibrolamellar Hepatocellular Carcinoma (FL-HCC) stem cells were isolated from ascites fluid using special culture conditions to select for cancer stem cells (CSCs) and were then transplanted into immunocompromised mice. Tumors formed and were established as a transplantable tumor line, that can be passaged from mouse to mouse. Such a tumor line is referred to as a patient-derived xenograft (PDX) model.

This PDX model is the first ever established of a human FL-HCC tumor. Extensive characterizations of this PDX model elucidated many of its phenotypic traits including the DNAJB1-PRKACA fusion transcript, characteristic of FL-HCC tumors.

These FL-HCC tumor cells are most easily maintained ex vivo in defined culture conditions as spheroids (purified tumor cells) or organoids (mix of tumor and mesenchymal cells). The PDX model is unique in being highly enriched (>60%) in cancer stem cells (CSCs), a property correlating with some of the devastating properties known for this type of cancer.

The initial detailed characterizations of this PDX model was reported in Nature Communications 2015 Oct 6;6:8070. doi: 10.1038/ncomms9070.a

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